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Leptin signaling and leptin resistance

null

《医学前沿（英文）》 2013年 第7卷 第2期   页码 207-222 doi: 10.1007/s11684-013-0263-5

摘要：

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain, particularly in the hypothalamus. These LEPRb-expressing neurons function as the first-order neurons that project to the second-order neurons located within and outside the hypothalamus, forming a neural network that controls the energy homeostasis and body weight. Multiple factors, including inflammation and endoplasmic reticulum (ER) stress, contribute to leptin resistance. Leptin resistance is the key risk factor for obesity. This review is focused on recent advance about leptin action, leptin signaling, and leptin resistance.

关键词： leptin signaling     leptin receptor     energy balance     leptin resistance     obesity    

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Simulation of bubble column reactors using CFD coupled with a population balance model

Tiefeng WANG

《化学科学与工程前沿（英文）》 2011年 第5卷 第2期   页码 162-172 doi: 10.1007/s11705-009-0267-5

摘要： Bubble columns are widely used in chemical and biochemical processes due to their excellent mass and heat transfer characteristics and simple construction. However, their fundamental hydrodynamic behaviors, which are essential for reactor scale-up and design, are still not fully understood. To develop design tools for engineering purposes, much research has been carried out in the area of computational fluid dynamics (CFD) modeling and simulation of gas-liquid flows. Due to the importance of the bubble behavior, the bubble size distribution must be considered in the CFD models. The population balance model (PBM) is an effective approach to predict the bubble size distribution, and great efforts have been made in recent years to couple the PBM into CFD simulations. This article gives a selective review of the modeling and simulation of bubble column reactors using CFD coupled with PBM. Bubble breakup and coalescence models due to different mechanisms are discussed. It is shown that the CFD-PBM coupled model with proper bubble breakup and coalescence models and interphase force formulations has the ability of predicting the complex hydrodynamics in different flow regimes and, thus, provides a unified description of both the homogeneous and heterogeneous regimes. Further study is needed to improve the models of bubble coalescence and breakup, turbulence modification in high gas holdup, and interphase forces of bubble swarms.

关键词： bubble column     computational fluid dynamics     bubble breakup and coalescence     population balance model     bubble size distribution    

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Gut microbial balance and liver transplantation: alteration, management, and prediction

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 123-129 doi: 10.1007/s11684-017-0563-2

摘要：

Liver transplantation is a conventional treatment for terminal stage liver diseases. However, several complications still hinder the survival rate. Intestinal barrier destruction is widely observed among patients receiving liver transplant and suffering from ischemia–reperfusion or rejection injuries because of the relationship between the intestine and the liver, both in anatomy and function. Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the process. This article reviews the research progress for gut microbial alterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut microbial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection of liver transplantation.

关键词： gut microbial balance     liver transplantation     ischemia–reperfusion     acute rejection    

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Nonlinear sealing force of a seawater balance valve used in an 11000-meter manned submersible

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0726-y

摘要： Balance valve is a core component of the 11000-meter manned submersible “struggle,” and its sealing performance is crucial and challenging when the maximum pressure difference is 118 MPa. The increasing sealing force improves the sealing performance and increases the system’s energy consumption at the same time. A hybrid analytical–numerical–experimental (ANE) model is proposed to obtain the minimum sealing force, ensuring no leakage at the valve port and reducing energy consumption as much as possible. The effects of roundness error, environmental pressure, and materials on the minimum sealing force are considered in the ANE model. The basic form of minimum sealing force equations is established, and the remaining unknown coefficients of the equations are obtained by the finite element method (FEM). The accuracy of the equation is evaluated by comparing the independent FEM data to the equation data. Results of the comparison show good agreement, and the difference between the independent FEM data and equation data is within 3% when the environmental pressure is 0–118 MPa. Finally, the minimum sealing force equation is applied in a balance valve to be experimented using a deep-sea simulation device. The balance valve designed through the minimum sealing force equation is leak-free in the experiment. Thus, the minimum sealing force equation is suitable for the ultrahigh pressure balance valve and has guiding significance for evaluating the sealing performance of ultrahigh pressure balance valves.

关键词： seawater balance valve     sealing performance     hybrid ANE model     FEM     minimum sealing force equation    

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ORGANIC CARBON STOCKS IN A SILTY TEXTURED SOIL FOLLOWING REINTEGRATION OF A 20 YEARS OLD × SITE INTO A CROP ROTATION

《农业科学与工程前沿（英文）》 2023年 第10卷 第2期   页码 183-197 doi: 10.15302/J-FASE-2023485

摘要：

● 0.98 Mg·ha−1·yr−1 Corg accumulation under miscanthus over 26 years.

关键词： biobased energy crops     C balance     humus accumulation    

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Quantitative analysis of yield and soil water balance for summer maize on the piedmont of the North China

Jingjing WANG,Feng HUANG,Baoguo LI

《农业科学与工程前沿（英文）》 2015年 第2卷 第4期   页码 295-310 doi: 10.15302/J-FASE-2015074

摘要： The North China Plain (NCP) is a major grain production area in China, but the current winter wheat-summer maize system has resulted in a large water deficit. This water-shortage necessitates the improvement of crop water productivity in the NCP. A crop water model, AquaCrop, was adopted to investigate yield and water productivity (WP) for rain-fed summer maize on the piedmont of the NCP. The data sets to calibrate and validate the model were obtained from a 3-year (2011–2013) field experiment conducted on the Yanshan piedmont of the NCP. The range of root mean square error (RMSE) between the simulated and measured biomass was 0.67–1.25 t·hm , and that of relative error (RE) was 9.4%–15.4%, the coefficient of determination ( ) ranged from 0.992 to 0.994. The RMSE between the simulated and measured soil water storage at depth of 0–100 cm ranged from 4.09 to 4.39 mm; and RE and in the range of 1.07%–1.20% and 0.880–0.997, respectively. The WP as measured by crop yield per unit evapotranspiration was 2.50–2.66 kg·m . The simulated impact of long-term climate (i.e., 1980–2010) and groundwater depth on crop yield and WP revealed that the higher yield and WP could be obtained in dry years in areas with capillary recharge from groundwater, and much lower values elsewhere. The simulation also suggested that supplementary irrigation in areas without capillary groundwater would not result in groundwater over-tapping since the precipitation can meet the water required by both maize and ecosystem, thus a beneficial outcome for both food and ecosystem security can be assured.

关键词： AquaCrop     summer maize     soil water balance     water productivity    

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Mass and heat balance calculations and economic evaluation of an innovative biomass pyrolysis project

Quanyuan WEI, Yongshui QU, Tianwei TAN

《化学科学与工程前沿（英文）》 2011年 第5卷 第3期   页码 355-361 doi: 10.1007/s11705-010-0567-9

摘要： Biomass can be converted into flammable gas, charcoal, wood vinegar, wood tar oil and noncombustible materials with thermo-chemical pyrolysis reactions. Many factors influence these processes, such as the properties of the raw materials, and temperature control and these will affect the products that are produced. Based on the data from a straw pyrolysis demonstration project, the mass and heat balance of the biomass pyrolysis process were analyzed. The statistical product and service solutions (SPSS) statistical method was used to analyze the data which were monitored on-site. A cost-benefit analysis was then used to study the viability of commercializing the project. The analysis included net present value, internal rate of return and investment payback period. These results showed that the straw pyrolysis project has little risk, and will produce remarkable economic benefits.

关键词： mass balance     heat balance     biomass pyrolysis     economic benefit    

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神经元之间的相位同步和能量平衡 Research Article

谢盈1,姚昭1,马军1,2

《信息与电子工程前沿（英文）》 2022年 第23卷 第9期   页码 1407-1420 doi: 10.1631/FITEE.2100563

摘要： 在一类简单的神经元电路不同支路嵌入光电管和热敏电阻来设计一种功能性神经元。通过光电管的光电流和流经热敏电阻的通道电流可以控制神经元电路的场能量。神经元的放电模态同时依赖于外界光照和温度。在不同的光照和温度刺激下，两个功能神经元存在能量差。因此，在场能量传递和交换过程中神经元之间开始建立突触连接并相互耦合。我们提出两种规则来讨论神经元之间突触耦合增强问题，神经元之间的能量差控制着神经元之间突触耦合强度的增长和突触电流变化，且神经元之间的同步有利于维持神经元之间的能量平衡。第一类规则类似于饱和增益法，即神经元在达到完全同步之前其突触耦合强度以恒定的增益周期性增长。第二类规则指出神经元突触耦合强度以恰当的增益呈现指数型增长，直到神经元之间达到能量平衡。两个不同的神经元在突触耦合增强的过程中可以实现相位同步。两个完全相同的神经元即使在噪声环境下，神经元耦合突触按照第二类规则增长强度依旧可以有效实现完全同步和能量平衡。此结果表明神经元突触更倾向于以指数型方式来增长其耦合强度。这些研究结果有助于揭示外界刺激如何唤醒和激活神经元之间的突触连接，进一步理解突触耦合电流时变的特性。潜在的生物物理机制在于外界差异性的刺激打破了神经元之间的能量平衡，因此突触耦合不断被增强来实现神经元之间能量动态平衡。这些研究结果为设计和训练智能神经元电路提供了思路，即通过设置梯度性能量分布来调控耦合通道。

关键词： 哈密顿能量；耦合同步；突触增强；神经元电路    

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Flow and mass balance analysis of eco-bio infiltration system

Marla C. MANIQUIZ, Lee-Hyung KIM, Soyoung LEE, Jiyeon CHOI

《环境科学与工程前沿（英文）》 2012年 第6卷 第5期   页码 612-619 doi: 10.1007/s11783-012-0448-1

摘要： A structured stormwater infiltration system was developed and constructed at a university campus and monitoring of storm events was performed during a one-year operation period. The flow and pollutant mass balances were analyzed and the overall efficiency of the system was assessed. While significant positive correlations were observed among rainfall, runoff and discharge volume ( = 0.93-0.99; <0.05), there was no significant correlations existed between rainfall, runoff, discharge volume and pollutant load. The system was more effective in reducing the runoff volume by more than 50% for small storm events but the difference between the runoff and discharge volume was significant even with rainfall greater than 10 mm. Results showed that the pollutant reduction rates were higher compared to the runoff volume reduction. Average pollutant reduction rates were in the range of 72% to 90% with coefficient of variation between 0.10 and 0.46. Comparable with runoff reduction, the system was more effective in reducing the pollutant load for small storm events, in the range of 80% to 100% for rainfall between 0 and 10 mm; while 65% to 80% for rainfall between 10 and 20 mm. Among the pollutant parameters, particulate matters was highly reduced by the system achieving only a maximum of 25% discharge load even after the entire runoff was completely discharged. The findings have proven the capability of the system as a tool in stormwater management achieving both flow reduction and water quality improvement.

关键词： best management practice     flow balance     low impact development     mass balance     nonpoint source     stormwater runoff    

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Deviation correction strategy for the earth pressure balance shield based on shield–soil interactions

《机械工程前沿（英文）》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0676-4

摘要： The control system presently used in shield posture rectification is based on driver experience, which is marginally reliable. The study of the related theory is flawed. Therefore, a decision-making approach for the deviation correction trajectory and posture rectification load for an earth pressure balance (EPB) shield is proposed. A calculation model of posture rectification load of an EPB shield is developed by considering the interactions among the cutter head, shield shell, and ground. The additional position change during the shield attitude correction is highlighted. The posture rectification loads and shield behaviors results can be solved by the proposed method. The influences of the stratum distribution (i.e., bedrock height in the upper-soft and lower-hard strata) on shield behaviors and posture rectification loads are analyzed. Results indicated that the increase of pitch angle in the upper-soft and lower-hard strata causes a sharp rise in vertical displacement. The bedrock height increases the magnitudes of the required posture rectification moments when hr/D > 0.5. For a tunnel with hr/D ≤ 0.5, the variation of hr/D has little effect on the posture rectification moments. Finally, the posture rectifying curves based on the theoretical model are compared with the target ones based on the double circular arc interpolation method. The required results can be obtained regardless of the soil–rock compound stratum distribution. The maximum rectification moment in the rock layer is almost 12.6 times that in the soil layer. Overall, this study provides a valuable reference for moment determination and the trajectory prediction of posture rectification in compound strata.

关键词： additional position change     deviation correction trajectory     earth pressure balance shield     mechanical model     posture rectification    

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Reliability of foam posturography in assessment of postural balance in the patients with vertigo

LIU Bo, KONG Weijia

《医学前沿（英文）》 2008年 第2卷 第4期   页码 361-365 doi: 10.1007/s11684-008-0069-z

摘要： The postural balance is a important aspect of assessment in vestibular rehabilitation therapy. As the computerized dynamic posturography, the foam posturography performed by using foam in posturography is a useful measurement tool for postural balance. Then, the reliability of foam posturography is critical in clinic. To our knowledge, there is no report about the test-retest reliability of foam posturography in the patients with vertigo in China. The foam posturography was taken on the patients with vertigo in stable state and repeated in 3 to 5 days. In the two assessments of test and retest, all subjects stood under 4 sensory conditions, such as firm surface with eyes open (T1), firm surface with eyes closed (T2), foam surface with eyes open (T3) and foam surface with eyes closed (T4) for 30 seconds respectively. The average sway velocity (SV) of center of pressure (COP) under feet of upright standing was recorded as research parameter. The results of patients with vertigo were compared with those of normal subjects. It demonstrated that all normal subjects did not fall in the two assessments. There were 10 of 34 patients with vertigo at least fell one time during the two assessments, and the SVs of these subjects did not taken the analysis of test-retest reliability. The results showed that: (1) The interclass correlation coefficients (ICC) of all 49 subjects including normal subjects and patients without falling were 0.887–0.973 according to the T1–T4 between two assessment. (2) The SVs between the normal subjects and patients were significantly different in the T2 ( = 2.018, = 0.049) and T4 ( = 3.905, < 0.001) in the first assessment and in the T4 ( = 3.715, = 0.001) in the second. And (3) the cases of falling between two assessments were not significant different ( = 0.073, = 0.787) in the patients with vertigo. It is concluded from this study that the foam posturography has high test-retest reliability to assess the postural balance in the patients with vertigo in stable state, indicating the foam posturography can be used as the valid means to assess the improvement of postural balance for patients with vertigo in the vestibular rehabilitation therapy.
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typical pharmaceutical and personal care products in a wastewater treatment plant from Beijing: a mass balance

Jie GAO,Jun HUANG,Weiwei CHEN,Bin WANG,Yujue WANG,Shubo DENG,Gang YU

《环境科学与工程前沿（英文）》 2016年 第10卷 第3期   页码 491-501 doi: 10.1007/s11783-016-0837-y

摘要： The fate and removal of pharmaceuticals and personal care products (PPCPs) in wastewater treatment plants (WWTPs) has received great attention during the last decade. Numerous data concerning concentrations in the water phase can be found in the literature, however corresponding data from sludge as well as associated mass balance calculations are very limited. In the present study, the adsorbed and dissolved concentrations of 9 PPCPs were investigated in each unit of a WWTP in Beijing, China. Based on the calculation of mass balance, the relative mass distribution and removal efficiency of each target compound was obtained at each process. The amount of PPCPs entering into the WWTP ranged from 12 g·d to 3848 g·d . Five target compounds (caffeine, chloramphenicol, bezafibrate, clofibric acid, and , -diethyl-meta-toluamide) were effectively removed, with rates of 57%–100%. Negative removal efficiencies were obtained for sulpiride, metoprolol, nalidixic acid, and carbamazepine, ranging from -19% to -79%. PPCPs mainly existed in dissolved form (≥92%) in both the raw influent and the final effluent. The sludge cake carried a much lower amount of PPCPs (17 g·d ) compared with the discharged effluent (402 g·d ). In A /O treatment tanks, the anaerobic and anoxic tanks showed good performance for PPCPs removal, and the amount of adsorbed PPCPs was increased. The results reveal that both the dissolved and the adsorbed phases should be considered when assessing the removal capacity of each A /O tank.

关键词： PPCPs     A2/O     mass balance     removal efficiency     sludge    

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Experimental study on the stratum applicability and mechanisms of bubble–slurry for earth pressure balance

《结构与土木工程前沿（英文）》   页码 1387-1399 doi: 10.1007/s11709-023-0005-y

摘要： Soil conditioning is essential for addressing the stratum applicability problem of earth pressure balance (EPB) shields. Under high water pressures, EPB shields spew water and soil when excavating coarse-grained strata. Typically, foam combined with polymers and slurry is used to solve spewing. However, in current techniques, slurry, foam, and the other agents are mixed with soil separately, their synergistic effect is seldom realized. In this study, an anionic surfactant was used to foam in bentonite slurry to form bubble–slurry to maximize the synergy between bubbles and slurry. The slump, volume stability, and permeability test of bubble–slurry-conditioned sand was conducted to examine the conditioning effect, and the stratum applicability of bubble–slurry was determined from the perspective of permeability. It was found that the conditioning effect of bubble–slurry in coarse gravel soil was excellent and could expand the applicability of EPB shields. The main stabilization mechanism of bubble–slurry is that bentonite particles provide a space barrier for bubbles. And three seepage modes of bubble–slurry-conditioned sand were innovatively defined, and the occurrence conditions of the three seepage modes were analyzed according to the permeability coefficient of sand, initial dynamic shear force of bubble–slurry, and hydraulic gradient.

关键词： EPB shield     bubble–slurry     soil conditioning     stability     permeability    

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GRASSLAND AGRICULTURE IN CHINA—A REVIEW

Fujiang HOU, Qianmin JIA, Shanning LOU, Chuntao YANG, Jiao NING, Lan LI, Qingshan FAN

《农业科学与工程前沿（英文）》 2021年 第8卷 第1期   页码 35-44 doi: 10.15302/J-FASE-2020378

摘要： Interactions between crops and livestock have been at the core of the evolution of many agricultural systems. In this paper, we identify the development and characteristics of mixed crop-livestock systems, with a focus on grassland-based systems, as these cover large areas in China, and face several challenges. Following the transition from the original hunting and foraging systems to a sedentary lifestyle with integrated crop-livestock production systems some 8000 years ago, a range of different mixed systems have developed, depending on rainfall, solar radiation and temperature, culture and markets. We describe 5 main types of integrated systems: (1) livestock and rangeland, (2) livestock and grain production, (3) livestock and crop – grassland rotations, (4) livestock, crops and forest (silvo-pasture), and (5) livestock, crops and fish ponds. Next, two of these mixed systems are described in greater detail, i.e., the mountain-oasis-desert system and its modifications in arid and semi-arid regions, and the integrated crop-livestock production systems on the Loess Plateau. In general, crop-livestock interactions in integrated systems have significant positive effects on crop production, livestock production, energy use efficiency and economic profitability. We conclude that improved integration of crop-livestock production systems is one of the most important ways for achieving a more sustainable development of animal agriculture in China.

关键词： food security     ruminant agriculture     herbivove agriculture     crop-livestock interaction     energy balance analysis    

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Analysis of catchment evapotranspiration at different scales using bottom-up and top-down approaches

Xiangyu XU, Dawen YANG,

《结构与土木工程前沿（英文）》 2010年 第4卷 第1期   页码 65-77 doi: 10.1007/s11709-010-0002-9

摘要： Physically-based hydrological models are used to predict catchment water balance through detailed simulation of hydrological processes at small temporal and spatial scales. However, annual catchment water balance can also be easily and simply predicted using lumped conceptual model. Comparison between physically-based hydrological models and lumped conceptual models can help us understand the dominant factors on catchment water balance at different scales. In this paper, a distributed physically-based hydrological model (i.e., bottom-up approach) and a simple water-energy balance model (i.e., top-down approach) are used to predict actual evapotranspiration in nine sub-catchments, and the whole basin of the Luan River in northern China. Both simulations give very close values of annual evapotranspiration and show the same complementary relationship between actual and potential evapotranspiration at annual time scale. From the analysis at different time scales through comparison of the top-down and the bottom-up methods, it is shown that the annual catchment evapotranspiration is controlled mainly by annual precipitation and potential evapotranspiration, and the variability of soil water and vegetation becomes more important at a smaller time scale in the study areas. It is also known that the relationship between potential and actual evapotranspiration shows a highly nonlinear relationship at the annual and catchment scale but can be simplified to a linear relationship at hourly temporal and hillslope scales, which is commonly used in the physically-based hydrological models.

关键词： catchment evapotranspiration     distributed hydrological model     water-energy balance model     top-down and bottom-up approaches    

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标题 作者 时间 类型 操作

Leptin signaling and leptin resistance

null

期刊论文

Simulation of bubble column reactors using CFD coupled with a population balance model

Tiefeng WANG

期刊论文

Gut microbial balance and liver transplantation: alteration, management, and prediction

null

期刊论文

Nonlinear sealing force of a seawater balance valve used in an 11000-meter manned submersible

期刊论文

ORGANIC CARBON STOCKS IN A SILTY TEXTURED SOIL FOLLOWING REINTEGRATION OF A 20 YEARS OLD × SITE INTO A CROP ROTATION

期刊论文

Quantitative analysis of yield and soil water balance for summer maize on the piedmont of the North China

Jingjing WANG,Feng HUANG,Baoguo LI

期刊论文

Mass and heat balance calculations and economic evaluation of an innovative biomass pyrolysis project

Quanyuan WEI, Yongshui QU, Tianwei TAN

期刊论文

神经元之间的相位同步和能量平衡

谢盈1,姚昭1,马军1,2

期刊论文

Flow and mass balance analysis of eco-bio infiltration system

Marla C. MANIQUIZ, Lee-Hyung KIM, Soyoung LEE, Jiyeon CHOI

期刊论文

Deviation correction strategy for the earth pressure balance shield based on shield–soil interactions

期刊论文

Reliability of foam posturography in assessment of postural balance in the patients with vertigo

LIU Bo, KONG Weijia

期刊论文

typical pharmaceutical and personal care products in a wastewater treatment plant from Beijing: a mass balance

Jie GAO,Jun HUANG,Weiwei CHEN,Bin WANG,Yujue WANG,Shubo DENG,Gang YU

期刊论文

Experimental study on the stratum applicability and mechanisms of bubble–slurry for earth pressure balance

期刊论文

GRASSLAND AGRICULTURE IN CHINA—A REVIEW

Fujiang HOU, Qianmin JIA, Shanning LOU, Chuntao YANG, Jiao NING, Lan LI, Qingshan FAN

期刊论文

Analysis of catchment evapotranspiration at different scales using bottom-up and top-down approaches

Xiangyu XU, Dawen YANG,

期刊论文